The Association Between Metformin and Folate Cycle Intermediates in Type 2 Diabetes Mellitus

Authors: Colin McCarthy, Kaitlyn Park

Field of Study: Science, Technology, Engineering, and/or Math

Faculty Mentors: Katie Edwards

Easel: 7

Timeslot: Afternoon

Abstract: While metformin is widely recognized for its ability to regulate blood glucose levels, emerging evidence suggests it may also influence metabolic pathways. This includes the folate cycle, which is crucial for one-carbon unit transfers, including DNA and amino acid synthesis. This study investigates the potential association between metformin use and changes in the intermediates of the folate cycle in individuals with type 2 diabetes mellitus. The data for this analysis was extracted from the National Health and Nutrition Examination Survey (NHANES). Until now, the relationship between metformin and folate cycle intermediates has been largely underexplored despite its potential implications for patient health. Utilizing R programming in accordance with the guidelines set by the Centers for Disease Control and Prevention (CDC), the biostatistical analysis of this association is thoroughly explored. Intermediates are expected to be lowered as metformin’s mechanism of action could have suppressive effects on the folate cycle.